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After Androgen Deprivation

Wed 31 Aug 2011

 Introduction Androgen Deprivation (ADT) can be an effective treatment for controlling prostate cancer for many years in most men. When ADT is no longer effective, you may be told that your cancer is “androgen-independent”, “hormone-resistant”, “hormone-refractory” or “castrate-resistant”. The terms all have similar meaning. For consistency, we will refer to CRPC. The nadir PSA isRead More ›

Side Effects of Androgen Deprivation Therapy Induced by Estrogen Deficiency

Sun 31 May 2009

Neal Shore, MD, Medical Director of the Carolina Urologic Research Center Myrtle Beach, South Carolina   and Stephen Freedland, MD Urologist, Duke Prostate Center at Duke University Durham, North Carolina Edited from PCRI Insights May, 2009 v 12.2 Introduction Testosterone plays an integral role in the progression of prostate cancer1; consequently, androgen deprivation therapy (ADT)Read More ›

Hormone-Refractory Prostate Cancer: A Continuum of Diseases and Options

Tue 1 Nov 2005

By Oliver Sartor, M.D., Chief, Hematology-Oncology Section; Director, Stanley S. Scott Cancer Center, LSU Medical Center, New Orleans Edited from PCRI Insights November, 2005 vol. 8 no.4 Introduction It is possible that hormones can sometimes cure, but unfortunately, that seems to be true only in a minority of patients. Certainly if the disease has becomeRead More ›

How Do You Treat Prostate Cancer That Has Progressed On Primary Androgen Deprivation Therapy? Part 2 of 2: Secondary Hormonal Treatment Approaches

Thu 1 Oct 1998

Revised October 1998     TABLE OF CONTENTS – PART 2 Page(s) Table of Contents 4 Overview 5 The antiandrogen withdrawal response (AAWR) 5-6 High-dose bicalutamide after flutamide withdrawal 6-7 High-dose ketoconazole (HDK) with hydrocortisone (HC) 7-13 Aminoglutethimide (AG) with hydrocortisone (HC) 12-13 Megestrol acetate 13-15 Corticosteroids 16 Estrogen therapy 17-18 Summary and a viewRead More ›