PCRI Papers

 

The sections below contain papers meant to inform you on the various aspects of prostate cancer. Most of the papers were originally published in the PCRI Insights newsletter. Many have been converted to Web pages with key terms linked to the PCRI Glossary. Some sections include references to additional articles that have been published in Insights with a PDF link to an image of the article (or issue). You can download these articles in Adobe Acrobat (PDF) format by using the links provided. If you would like to receive a printed copy of the issue, contact the PCRI Helpline.

Some of these Papers contain opinions of the authors based on their clinical practice or research at the time of the article and may not reflect their current thinking. Information provided in these papers should not be taken as medical advice and should be discussed with a patient's physicians.

Basics

     Nutrition

• Update On Omega 3 and Prostate Cancer – Mark Moyad, MD, MPH PDF  August 2011
• Diet, Vitamins & Exercise for Prostate Cancer PCRI Pamphlet 2010
• Herbal, All Natural – Are they safe? Are they effective? PDF Stanley Brosman, MD 2010
• Integrative Medicine and Prostate Cancer: A Look at the Currently Available Evidence PDF Geo Espinosa, ND 2009
• Food For Thought: Pomegranate Juice and Tomato Products Show Promise PDF Mark Dreher, Ph.D. 2009
• Pomegranates and Prostate Health: A Research Report • Mark Dreher, Ph.D. 2008
• Advances in Holistic PC Chemoprevention and Treatment • Aaron Katz, M.D. 2008
• Can Natural Dietary Supplements Really Impact Prostate Cancer? • Jacek Pinski, MD, PhD 2007
• Can Diet Really Control Prostate Cancer? • Mark Scholz, MD and Ralph Blum 2006
• The Linkage Between Obesity and Prostate Cancer • David Heber, MD, PhD, FACP, FACN May 2004

Undiagnosed

     Pre-Clinical Phase

• Infection Associated With Prostate Biopsies 1 – Paul Schellhammer, MD PDF 2011
• Eleven Decisions Before Prostate Biopsy PDF 2011
• Screening for Prostate Cancer PCRI Pamphlet 2010
• Prostate Disorders Other Than Cancer – Part 1 Prostatitis PDF • Stanley Brosman, MD 2010
• Prostate Disorders Other Than Cancer – Part 2 BPH PDF • Stanley Brosman, MD 2010
• Chemoprevention of Prostate Cancer PDF • Paul Schellhammer, MD 2010
• For Your Sons PDF • Jan Manarite 2009
• What Do We Know About PSA Screening Now That It's 2009? PDF
• PSA Doubling Time 2009 (update)
• PCA3: A Genetic Marker of Prostate Cancer • Alejandra B.Torres and Leonard S.Marks, MD 2006
• What Every Doctor Who Treats Male Patients Should Know • Stephen B. Strum, MD, FACP and Donna Pogliano 2005
• The PCRI Views Regarding Testing for Prostate Cancer 2004
• Using PSA Intelligently to Manage Prostate Cancer, Part 1 • Jonathan McDermed, PharmD 2003
  • Part 2 2005
• Prostatic Intraepithelial Neoplasia PIN 1998

Newly Diagnosed

     Self-Empowerment

• Newly-Diagnosed – the Very Basics • Mark Scholz, MD and Richard Lam, MD 2008
• Finding the Best Treatment • Mark Scholz, MD 2004
• E-Empowerment • Arthur Lurvey, MD 2004
• Levels of Evidence PDF 2009
• What We Should Have Learned about PC in the Last 10 Years. – Stephen B. Strum, MD, FACP 2008
  • Part 1 – Prostate Cancer Landscape and the Potential for Prevention
  • Part 2 – Exploring the Lessons from the Prostate Cancer Prevention Trial
  • Part 3 – The Use the PSA and Derivative Tools in Diagnosis and Staging
• The PCRI Glossary: A Tool for Learning About PC
• Who's At Risk for What? • Mark Scholz, MD 2005
  • Laboratory Tests Defined May, 2005
• Participating in a Prostate Cancer Clinical Trial • Stanley A. Brosman, MD 2005

     Risk Assessment and Algorithms

• Prostate Cancer Algorithms/Nomograms  2011 (updated)
• Risk Assessment for Prostate Cancer PDF • Matthew R. Cooperberg, MD, MPH 2010
• Partin Tables for Predicting Extent of Disease 2009 (updated)
• Newly Diagnosed PC: Evaluating the Options (Part 1 – Introduction) • Mark Scholz, MD 2003
• A Strategy Of Success in the Treatment of Prostate Cancer • Stephen B. Strum MD 2002
• Creating Your PC Digest – v1.1, PDF 1998

     Staging

• Targeted Biopsies and Active Surveillance PDF • David B. Agus, MD 2010
• Should a Second Opinion be Obtained When a Biopsy is Positive? PDF • Stanley Brosman, MD 2010
• The Great Prostate Cancer Stage Migration PDF 2009
• Gleason Grade Migration: Changes in Prostate Cancer Grade in the Contemporary Era • Daniel J. Luthringer, MD and Mitchell Gross, MD 2006
• Does Finasteride Alter the Pathology of the Prostate and Cancer Grading? • David G. Bostwick MD 2004
• The Gleason Score: Prostate Cancer Aggressiveness On Biopsy • Gerry J. O’Dowd et al 2001
• Ploidy Analysis 2000
• The Clinical Stage: Its Definition and Importance in Prostate Cancer • Harry Pinchot and Stephen B. Strum MD 2000
• Understanding Your Biopsy Results 1998

     Diagnostic Scanning

• MRI for Prostate Cancer PDF • Daniel J A Margolis, MD 2010
• MRI in Prostate Cancer • Jelle Barentsz, M.D., Ph.D 2008
• Magnetic Resonance Anatomic and Spectroscopic Imaging of Prostate Cancer – Current Status • John Kurhanewicz, Christopher K. Sotto and Fergus Coakley 2006
• Ferumoxtran-10 (Combidex): An Important New Prostate Cancer Staging Tool • Maha Torabi, MD and Mukesh G. Harisinghani, MD 2004
• Update on ProstaScint: CT and MRI Fusion as Diagnostic Tools • Samuel Kipper, MD 2003
• Color Doppler and Tissue Harmonic Ultrasound • Duke Bahn, MD 2002
• Endorectal MRI with spectroscopy • UCSF Prostate Cancer MRI/MRSI Group 2000

Local Therapies

     Treatment for Localized Disease

• Salvage Options for Rising PSA After Primary Therapy – Nathan Roundy PDF 2011
• Salvage Cryotherapy – Duke Bahn, MD PDF
• Salvage Brachytherapy – Paul Song, MD PDF 2011
• Update On Image-Guided Radiation Therapy PDF • Patrick Kupelian, MD 2011
• How to Pick the Best Treatment for Prostate Cancer PCRI Pamphlet 2010
• Treatment Choices for Early (Localized) Prostate Cancer PDF • Grace Lu-Yao, PhD & Siu-Long Yao, MC 2010
• Long Term Results of Surgery for Localized PC PDF • Stanley Brosman, MD 2010
• Nine Decisions Before Choosing Radiation Therapy After Prostatectomy PDF 2010
• Salvage High Dose Rate Brachytherapy After Radiation • Paul Y. Song, M.D. 2008
• Active Surveillance with High Resolution Color-Doppler Transrectal Ultrasound Monitoring • Duke Bahn, MD, Mark Scholz, MD, and Richard Lam, MD 2007
• High Dose Rate (HDR) Brachytherapy • D. Jeffrey Demanes MD, FACRO, FACR 2007
• Nerve Sparing Robotic Prostatectomy -Update • Ashutosh Tewari, MD 2007
• Active Surveillance For Favorable Risk Prostate Cancer:
  What Are The Results, and How Safe Is It? – Laurence Klotz, MD et al. 2006
• Cryoablation of the Prostate • Duke K. Bahn, MD, et al. 2005
• Nerve Sparing Robotic Prostatectomy • Ashutosh Tewari, MD, Mani Menon, MD, et al 2004
• Intensity Modulated Radiation Therapy (IMRT) • Lisa Chaiken, MD, et al. 2004
• Newly Diagnosed PC: Evaluating the Options (Part 2 – for lower risk patients) • Mark Scholz, MD 2003
  1. Deferred therapy (previously known as watchful waiting)
  2. Androgen deprivation therapy (ADT)
  3. Brachytherapy (Seeds)
  4. Surgery (radical prostatectomy)
  5. Intensity modulated radiation therapy (IMRT)
  6. Cryotherapy (Cryo)
  7. High Dose Radiation (HDR) Monotherapy
• Which PC Therapy Has the Best Long Term PSA Control? PDF
• Radical Prostatectomy • Stanley Brosman, MD 2003
• Prostate Seed Implantation for Prostate Cancer • Peter Grimm, DO, et al. 2003
• Temporary Seed Implant with High Dose Rate Brachytherapy (HDR) • Glenn Gejerman, MD 2003

  Novel Therapies

• HIFU Treatment Outcome Data Is Maturing PDF 2011
• Review of Focal Therapy for Localized Prostate Cancer PDF 2010
• Has the Time Come for Focal Therapy of Prostate Cancer? • Martin J Weissman, M.D. 2008
• CancerCryo-Immunotherapy: A Battle Between the Immune System and Cancer • Haakon Ragde, MD and Duke K. Bahn, MD 2006
• Transrectal High Intensity Focused Ultrasound: The Next Generation? • HIFU • Douglas O. Chinn, MD 2005

      Systemic Therapies

• Newly Diagnosed PC: Evaluating the Options (Part 3 – for higher risk patients) • Mark Scholz, MD 2004

      Androgen Deprivation Therapy

• Preventing Side Effects from Testosterone Inactivating Pharmaceuticals – Mark Scholz, MD 2010
• Avodart and Proscar • Mark Scholz, MD 2010
• Immune Treatment for PSA-Relapsed Prostate Cancer • Mark Scholz, MD 2010
• Bisphosphonates for Osteoporosis or Bone Metastasis • Mark Scholz, MD 2010
• Testosterone Inactivating Pharmaceuticals • Mark Scholz, MD 2010
• Testosterone Inactivating Pharmaceuticals PDF • Mark Scholz, MD & Ralph Blum 2010
• Anti-androgen Monotherapy • Mark Scholz, MD 2010
• Beating Prostate Cancer with Hormonal Therapy • Charles Myers, MD 2007
• Preventing and Treating the Side Effects of Testosterone Deprivation Therapy – Brad Guess PA-C 2006
• Adjuvant Androgen Withdrawal • Glenn Tisman, MD 2003
• Intermittent Androgen Deprivation • Stephen B. Strum, MD 2000
• Importance of Concordance in PC Management 2000

      Secondary Hormonal Therapy and Androgen Resistance

• Anti-androgen Withdrawal Response (AAWR)
• High Dose Ketoconazole Plus Hydrocortisone (HDK+ HC) 2004
• Androgen Resistance (Part 1) • Charles Myers, MD 2002
• Androgen Resistance (Part 2) 2003
• Androgen Resistance (Part 3) 2003

      Androgen Independent PC

• New FDA Approval for Cabazitaxel (Jevtana®) PDF • Oliver Sartor, MD 2010
• PROVENGE® Approved in the U.S.A. PDF • Jan Manarite 2010
• Chemotherapy in Prostate Cancer • Richard Lam, MD 2009
• Empowerment In Advanced & Hormone Refractory PC PDF • Jan Manarite 2009
• Dealing with Taxotere Side Effects • Richard Lam, MD 2007
• Chemotherapy for Prostate Cancer: "Why Bother?" • Brad Guess, PA-C 2006
• Hormone-Refractory Prostate Cancer: A Continuum of Diseases and Options • Oliver Sartor, MD 2005
• Listening to the Biology of PC • Stephen Strum, MD 2001
• Important Principles in Chemotherapy (AIPC) • Stephen Strum, MD 1999
• How do you Treat PC that has Progressed on Primary ADT?: Part 1 1998
• How do you Treat PC that has Progressed on Primary ADT?: Part 2
• Logothetis Protocol 1998
• Cytoxan 1997

      High Risk Prostate Cancer

• Bone -Targeted Therapy for Advanced Prostate Cancer • Oliver Sartor, MD 2009
• Newer Concepts in the Treatment of Hormone-Refractory Prostate Cancer with Bone Metastases • Oliver Sartor, MD 2005
• Bone integrity relation to PC activity: extent of disease vs survival - v2.2, PDF 1999
• Bagley Regimen • Stephen B. Strum, MD 1998
• Servadio regimen of DES + Cytoxan + 5FU – 1998 v1.1, PDF
• Small Cell PC 1994

  Novel Therapies

• Cabozantinib (XL184) Phase II PDF • Mark Scholz, MD 2011
• The Abscopal Effect – Using Cancer Against Itself – By William Cavanagh 2009
• Immunotherapy And Advanced Prostate Cancer – By William Cavanagh 2008
• Update on Provenge Trials – Nov 2006
• Update on Provenge Trials – Sept 2005
• Dendritic Cells – Key to PC Immunotherapy • Frank Valone, MD - v4.4 PDF 2001
• Introduction to Monoclonal Antibodies 1996

      Treatment Side Effects

• Radiation Cystitis – Stanley Brosman, MD PDF 2011
• Side Effects of Androgen Deprivation Therapy Induced by Estrogen Deficiency – Neal Shore, MD& Stephen Freedland, MD 2009
• Stenting of the Urethra for the Treatment of Urinary Complications Related to the Prostate PDF 2009
• Dealing with Taxotere Side Effects – Richard Lam, MD 2007
• Preventing and Treating the Side Effects of Testosterone Deprivation Therapy – Brad Guess PA-C 2006
• The Treatment of Erectile Dysfunction • Stephen M.Auerbach, MD 2005
• Photoselective Vaporization Prostatectomy: A Palliative Treatment Option for Men with Urinary Obstruction Secondary to Prostate Cancer • Mahmood A. Hai MD, FACS 2005
• Incontinence Treatment Options for Post-Prostatectomy • Gary E. Leach, MD 2004
• Androgen Deprivation Syndrome (ADS) • Stephen B. Strum, MD 1999
• Important Principles in Chemotherapy (AIPC) • Stephen Strum, MD 1999

      Bone Integrity

• Bisphosphonates for Osteoporosis or Bone Metastasis • Mark Scholz, MD 2010
• Bone Integrity – in depth review • Stephen Strum, MD 1999
• Association between bone formation and destruction – 1999 v2.2, PDF

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