New Clinical Trials for Prostate Cancer

Participation in clinical trials is critical to the approval cycle for new treatments. It is usually the only way a patient can gain access to the latest innovative therapies. While PCRI does not endorse specific trials, we want you to be aware of what’s available. This page includes new clinical trials recently added to www.clinicaltrials.gov, a service of the U.S. National Institutes of Health. For more information on clinical trials, click here:

Added April 7, 2008

Treatment of Slow-Growing Recurrent Prostate Cancer with Vitamin D3
FCRE - Phase II - Currently Recruiting - Location: Earlysville, VA Contact # 434-220-4539

CyberKnife Radiosurgery for Organ-Confined Prostate Cancer: Homogenous Dose Distribution
NCT00643994 - Phase II - Currently Recruiting - Location: Seattle WA

CyberKnife Radiosurgery For Low & Intermediate Risk Prostate Cancer: Emulating HDR Brachytherapy Dosimetry
NCT00643617 - Phase II - Currently Recruiting - Location: San Diego CA

Satraplatin and Prednisone in Treating Patients With Progressive, Metastatic Prostate Cancer
NCT00634647 - Phase II - Currently Recruiting - Location: Bethesda MD

Paricalcitol in Treating Patients With Advanced Prostate Cancer and Bone Metastases
NCT00634582 - Phase II - Not yet Recruiting - Location: Wake Forest NC

Study of INCB018424 Administered Orally to Patients With Androgen Independent Metastatic Prostate Cancer
NCT00638378 - Phase II - Currently Recruiting - Location: Various in USA

Phase II Study Evaluating Toxicity and Efficacy of Lenalidomide (Revlimid®) in Chemotherapy-Naïve Androgen Independent Prostate Cancer Patients
NCT00654186 - Phase II - Currently Recruiting - Location: Niles IL

Abiraterone Acetate in Castration-Resistant Prostate Cancer Previously Treated With Docetaxel-Based Chemotherapy
NCT00638690 - Phase III - Not yet Recruiting - Location: New York NY and Sutton UK

A Multi-Center Phase II Study to Compare MER-101 (20mg) Tablets to Intravenous Zometa 4mg in Male Bisphosphonate-Naive, Hormone Refractory Prostate Cancer Patients
NCT00636740 - Phase II - Currently Recruiting - Location: Various in USA

A Phase I Study of BMS-641988 in Japanese Patients With Castration Resistant Prostate Cancer
NCT00644488 - Phase I - Not yet Recruiting - Location: Not Announced

Adjuvant Treatment of Prostate Cancer (AdRad)
NCT00653848 - Phase III - Currently Recruiting - Location: Oslo, Norway

Androgen Suppression Therapy and Radiation Therapy With or Without Docetaxel in Treating Patients With High-Risk Localized Prostate Cancer
NCT00651326 - Phase III - Not yet Recruiting - Location: British Columbia Canada

Watchful Waiting, Radical Prostatectomy, or Radiation Therapy in Treating Patients With Localized Prostate Cancer
NCT00632983 - Phase III - Currently Recruiting - Location: Various in UK

Molecular, Genetic, and Genomic Assessments From Patients Treated With RAD001
NCT00636090 - Phase NA - Currently Recruiting - Location: Durham NC

Pelvic Floor Muscle Training and Biofeedback or Standard Therapy in Men Who Have Undergone Radical Prostatectomy or Transurethral Resection of the Prostate
NCT00632138 - Phase III - Currently Recruiting - Location: Various in UK

Coxsackie Virus A21 Administered IV for Solid Tumour Cancers
NCT00636558 - Phase I - Not yet Recruiting - Location: Brisbane Australia

Use of Organic Germanium or Placebo for the Prevention of Radiation Induced Fatigue
NCT00651417 - Phase II - Currently Recruiting - Location: Phoenix AZ

CASODEX 150-mg Compassionate Use - Prostate Cancer
NCT00636259 - Phase NA - Currently Recruiting - Location: contact AstraZeneca

Added March 7, 2008

Stereotactic Radiation Therapy in Treating Patients With Prostate Cancer
NCT00619515 - Phase NA - Currently Recruiting - Location: Cleveland Ohio

Mitoxantrone, Etoposide, and Vinorelbine As Second-Line Therapy in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy
NCT00627354 - Phase 2 - Currently Recruiting - Location: Caen, France

Phase II Study of Sorafenib and Docetaxel in Metastatic Prostate Cancer (GAO1)
NCT00619996 - Phase 2 - Currently Recruiting - Location: Pisa, Italy

RAD001 and Bicalutamide for Androgen Independent Prostate Cancer
NCT00630344 - Phase 2 - Currently Recruiting - Location: Boston, Massachusetts

Sunitinib Malate, Hormone Ablation and Radiation Therapy in Patients With Prostate Cancer
NCT00631527 - Phase 1 - Currently Recruiting - Location: Houston, Texas

Vaccine Therapy in Treating Patients With Metastatic, Progressive Prostate Cancer
NCT00616291 - Phase 1 - Currently Recruiting - Location: Houston, Texas

The Specific Role of Isoflavones in Reducing Prostate Cancer Risk
NCT00617617 - Phase 2 - Currently Recruiting - Location: Tampa, Florida

Efficacy and Safety Study of a New Leuprolide Acetate 17 mg Depot to Treat Prostate Cancer Patients
NCT00630799 - Phase 3 - Not yet Recruiting - Location: Not announced as yet

RAD001 in Patients With Metastatic, Hormone-Refractory Prostate Cancer
NCT00629525 - Phase 2 - Currently Recruiting - Location: Durham, North Carolina

A Safety Trial of MVA-BN®-PRO in Men With Androgen-Insensitive Prostate Cancer (BNIT-PR-001)
NCT00629057 - Phase 1 - Not yet Recruiting - Location: Several in USA

Phase I Gene Therapy Study of FP253/Fludarabine for Prostate Cancer (FP253-GDEPT)
NCT00625430 - Phase 1 - Not yet Recruiting - Location: Darlinghurst, New South Wales, Australia

A Study of Leuprolide 45 mg (6 month) Formulation to Treat Prostate Cancer
NCT00626431 - Phase 3 - Currently Recruiting - Location: Various in USA

Observation of Outcomes and Side Effects of Cesium-131 in Combination With External Beam Radiation for the Treatment of Intermediate to High Risk Prostate Cancer
NCT00621413 - Phase NA - Currently Recruiting (by invitation) - Location: Several in USA

Bortezomib and Gemcitabine in Treating Older Patients With Advanced Solid Tumors
NCT00620295 - Phase 1 - Currently Recruiting - Location: Minneapolis, Minnesota

USPIO-Enhanced and Diffusion-Weighted MRI for the Detection of Pelvic Lymph Node Metastases
NCT00622973 - Phase 3 - Currently Recruiting - Location: Bern, Switzerland

A Phase 1 Study of Mixed Bacteria Vaccine (MBV) in Patients With Tumors Expressing NY-ESO-1 Antigen
NCT00623831 - Phase 1 - Currently Recruiting - Location: Frankfurt, Germany

Added February 1, 2008

Safety and Efficacy Study of Leuprolide Acetate for Injectable Suspension 22.5 MG in the Treatment of Prostate Cancer
NCT00598312 – Phase 3 – Currently Recruiting – Location: Oakwood Village, Ohio

Neoadjuvant Docetaxel on Newly Diagnosed Intermediate and High Grade Cancer of the Prostate (2007-5904)
NCT00598858 – Phase 3 – Not Yet Recruiting – Location: Orange, California

High Dose Rate Prostate Brachytherapy as Salvage for Locally Recurrent Prostate Cancer Previously Treated With External Beam Radiotherapy
NCT00604526 – Phase ? – Currently Recruiting – Location: New York, NY

Study of DNA Mutations in Predicting the Effect of External-Beam Radiation Therapy in Patients With Early Breast Cancer, Localized Prostate Cancer, or Gynecological Cancer
NCT00601406 – Phase ? – Currently Recruiting – Location: various in United Kingdom

Pharmacokinetic Study of Abiraterone Acetate Tablets and Capsules Followed by Safety and Efficacy Evaluation of Continuous Tablet Dosing
NCT00600535 – Phase 1 – Not Recruiting – Location: Los Angeles, CA, Sutton & Glasgow, United Kingdom

Phase II Sunitinib Prog Met AIPC
NCT00599313 – Phase 2 – Not Recruiting – Location: various in United States

Soy Derivatives for Control of Hot Flashes in Men on Androgen Deprivation Therapy
NCT00594620 – Phase 2 – Currently Recruiting – Location: Toronto, Canada

Efficacy Study of Methylphenidate Hydrochloride to Reduce Fatigue in Prostate Cancer Patients Receiving Hormone Therapy
NCT00593853 – Phase 2 – Currently Recruiting – Location: Toronto, Canada

Fentanyl Sublingual Spray in Treating Cancer Patients With Breakthrough Pain
NCT00589004 – Phase 3 – Currently Recruiting – Location: Phoenix, Arizona

Study of Polyphenon E in Men With High-Grade Prostatic Intraepithelial Neoplasia
NCT00596011 – Phase 3 – Currently Recruiting – Location: Tampa, Chicago, Philadelphia

 

Prostate Cancer Research Institute (PCRI)
 

Material provided by PCRI is intended for educational purposes for discussion with your physician and should not be considered as medical advice. Information and opinions expressed on this website are not an endorsement by PCRI for any treatment, product or service.